您提到了 * 缓存 *，所以我认为您看到所描述的情况的唯一方式是您正在重置缓存，以便DataGridview重新绑定到一个新的源。
您可以使用DataGridView.SortedColumn Property和DataGridView.SortOrder Property存储当前的排序状态。然后进行更新。更新后，恢复存储的排序状态。

' since it is asumed that the datasource changes, store only the column name
  Dim sortColName As String = dgv1.SortedColumn?.Name 'dgv1.SortedColumn may be null
  Dim direction As SortOrder = dgv1.SortOrder

  UpdateData() ' replace this with your Update code

  ' restore the sort state if any
  If sortColName IsNot Nothing Then
    Dim columnToSort As DataGridViewColumn = dgv1.Columns(sortColName)
    If columnToSort IsNot Nothing Then
      Dim directionProgrammatic As System.ComponentModel.ListSortDirection
      Select Case direction
        Case SortOrder.Ascending
          directionProgrammatic = System.ComponentModel.ListSortDirection.Ascending
        Case SortOrder.Descending
          directionProgrammatic = System.ComponentModel.ListSortDirection.Descending
      End Select
      dgv1.Sort(columnToSort, directionProgrammatic)
      columnToSort.HeaderCell.SortGlyphDirection = direction
    End If
  End If

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添加用C#编写的答案，与TnTinMn相同

var sortColName = dgv1.SortedColumn;
var sortDirection = dgv1.SortOrder;

UpdateData() ' replace this with your Update code

if (sortColName != null)
{
     dgv1.Sort(sortColName,
          sortDirection == SortOrder.Ascending
              ? ListSortDirection.Ascending
              : ListSortDirection.Descending);
 }

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